Table 1.
The list of candidate neo-epitopes encoded by CMS7 tumor.
| ID | length | peptide | Allele | IC50 (nM) | Symbol | n Change | a.a.Change | Entrez gene name |
|---|---|---|---|---|---|---|---|---|
| C7-1 | 10 | RGPLNLFETC | H-2-Dd | 2854 | Plekhg5 | c.G176T | p.C59F | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 |
| C7-2 | 8 | VPPAALRL | H-2-Ld | 101 | Anapc2 | c.G157C | p.G53R | anaphase promoting complex subunit 2 |
| C7-3 | 8 | TPLNILAL | H-2-Ld | 64 | Gba | c.G325C | p.A109P | glucosidase, beta, acid |
| C7-4 | 8 | LPVATVTL | H-2-Ld | 98 | Il6ra | c.G119T | p.G40V | interleukin 6 receptor, alpha |
| C7-5 | 8 | YAPCRGEF | H-2-Dd | 1371 | Snd1 | c.C2191T | p.R731C | staphylococcal nuclease and tudor domain containing 1 |
| C7-6 | 8 | LPACKFQL | H-2-Ld | 95 | Trappc6a | c.G460T | p.V154L | trafficking protein particle complex 6A |
| C7-7 | 9 | SPYQPKYGF | H-2-Ld | 47 | Trim12c | c.A1193C | p.H398P | tripartite motif-containing 12C |
| C7-8 | 8 | VPAEALSF | H-2-Ld | 98 | Dnase2a | c.G65T | p.C22F | deoxyribonuclease II alpha |
| C7-9 | 10 | QYAPAAPSEV | H-2-Kd | 248 | 2810004N23Rik | c.C266A | p.S89Y | RIKEN cDNA 2810004N23 gene |
| C7-10 | 8 | CGPLKLLV | H-2-Dd | 1399 | Supv3l1 | c.C710T | p.A237V | suppressor of var1, 3-like 1 (S. cerevisiae) |
| C7-11 | 8 | YPNRFLHM | H-2-Ld | 42 | Gnptab | c.G3503C | p.R1168P | N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits |
| C7-12 | 8 | IPFCLQSF | H-2-Ld | 44 | Gls2 | c.G659T | p.C220F | glutaminase 2 (liver, mitochondrial) |
| C7-13 | 9 | LYLPMVQSV | H-2-Kd | 23 | Dazap2 | c.C224T | p.A75V | DAZ associated protein 2 |
| C7-14 | 10 | PYSSPSPTAV | H-2-Kd | 332 | Ncoa1 | c.G3026T | p.G1009V | nuclear receptor coactivator 1 |
| C7-15 | 8 | EPPDHLTI | H-2-Dd | 2660 | Cep170 | c.A4151C | p.H1384P | DAZ associated protein 2 |
| C7-16 | 8 | RPAPKSFL | H-2-Ld | 119 | Samhd1 | c.A973C | p.T325P | SAM domain and HD domain, 1 |
| C7-17 | 8 | RGPLNLFE | H-2-Dd | 2340 | Plekhg5 | c.G176T | p.C59F | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 |
| C7-18 | 9 | RGPLNLFET | H-2-Dd | 3519 | Plekhg5 | c.G176T | p.C59F | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 |
| C7-19 | 8 | EPKQYFDL | H-2-Ld | 203 | Tjp1 | c.A3578T | p.Q1193L | tight junction protein 1 |
| C7-20 | 8 | DSPYQPKY | H-2-Dd | 2865 | Trim12c | c.A1193C | p.H398P | tripartite motif-containing 12C |
| C7-21 | 9 | SYYLSAGMV | H-2-Kd | 53 | Slc37a2 | c.C343A | p.R115S | solute carrier family 37 (glycerol-3-phosphate transporter), member 2 |
| C7-22 | 8 | MPLEQWWL | H-2-Ld | 135 | Pfkl | c.G2210T | p.R737L | phosphofructokinase, liver, B-type |
| C7-23 | 9 | KIPFCLQSF | H-2-Dd | 2320 | Gls2 | c.G659T | p.C220F | glutaminase 2 (liver, mitochondrial) |
| C7-24 | 9 | ISPGEEMQF | H-2-Dd | 1949 | Timeless | c.G1923C | p.L641F | timeless circadian clock 1 |
| C7-25 | 8 | LGPPRSSP | H-2-Dd | 2125 | Sh3bp5l | c.G857C | p.R286P | SH3 binding domain protein 5 like |
| C7-26 | 8 | GPPRSSPV | H-2-Dd | 2437 | Sh3bp5l | c.G857C | p.R286P | SH3 binding domain protein 5 like |
| C7-27 | 9 | LGPPRSSPV | H-2-Dd | 711 | Sh3bp5l | c.G857C | p.R286P | SH3 binding domain protein 5 like |
| C7-28 | 9 | KYANRSRNI | H-2-Kd | 52 | Kif21a | c.G1102T | p.A368S | kinesin family member 21A |
| C7-29 | 8 | FAPRHSRL | H-2-Dd | 2431 | Zfp598 | c.G881T | p.R294L | zinc finger protein 598 |
| C7-30 | 8 | QPPNLIGL | H-2-Dd | 2728 | Rbm27 | c.G1379C | p.R460P | RNA binding motif protein 27 |
| C7-31 | 9 | WFQAMANGL | H-2-Kd | 106 | Strbp | c.G632T | p.R211M | spermatid perinuclear RNA binding protein |
| C7-32 | 8 | CGPRPRRS | H-2-Dd | 3179 | Rpp25l | c.G471T | p.R157S | ribonuclease P/MRP 25 subunit-like |
| C7-33 | 9 | TTPATSTTF | H-2-Dd | 3370 | Cnot1 | c.G4025T | p.C1342F | CCR4-NOT transcription complex, subunit 1 |
| C7-34 | 9 | TYMSSVCWL | H-2-Kd | 22 | Siae | c.G580T | p.A194S | sialic acid acetylesterase |
| C7-35 | 9 | CGPLKLLVH | H-2-Dd | 1423 | Supv3l1 | c.C710T | p.A237V | suppressor of var1, 3-like 1 (S. cerevisiae) |
| C7-36 | 9 | TIMVIVFFL | H-2-Ld | 790 | H2-DMa | c.G740T | p.G247V | histocompatibility 2, class II, locus DMa |
| C7-37 | 8 | NYRPVALL | H-2-Kd | 1674 | Pten | c.G559A | p.D187N | phosphatase and tensin homolog |
| C7-38 | 8 | RMPSSAAI | H-2-Dd | 3632 | Nfe2l2 | c.A865C | p.S289R | nuclear factor, erythroid derived 2, like 2 |
| C7-39 | 8 | PAPKSFLY | H-2-Dd | 3642 | Samhd1 | c.A973C | p.T325P | SAM domain and HD domain, 1 |
| C7-40 | 10 | VYKWVGSSTA | H-2-Kd | 1466 | Exoc1 | c.C305G | p.A102G | exocyst complex component 1 |
| C7-41 | 8 | FPTDCHSI | H-2-Ld | 482 | Atg2b | c.G1858A | p.V620I | autophagy related 2B |
| C7-42 | 8 | LGPEGYSV | H-2-Dd | 3825 | Cyhr1 | c.G335A | p.C112Y | cysteine and histidine rich 1 |
| C7-43 | 10 | CYRRASSCSL | H-2-Kd | 164 | Ripk2 | c.G1219T | p.D407Y | receptor (TNFRSF)-interacting serine-threonine kinase 2 |
| C7-44 | 10 | SYYLSAGMVL | H-2-Kd | 137 | Slc37a2 | c.C343A | p.R115S | solute carrier family 37 (glycerol-3-phosphate transporter), member 2 |
| C7-45 | 9 | SPGEEMQFL | H-2-Ld | 154 | Timeless | c.G1923C | p.L641F | timeless circadian clock 1 |
| C7-46 | 10 | LYLPMVQSVA | H-2-Kd | 547 | Dazap2 | c.C224T | p.A75V | DAZ associated protein 2 |
| C7-47 | 8 | RPVNLMEV | H-2-Ld | 749 | Tbc1d19 | c.G1465C | p.A489P | TBC1 domain family, member 19 |
| C7-48 | 9 | FPLQGLHKL | H-2-Ld | 23 | Tbc1d1 | c.G1151T | p.C384F | TBC1 domain family, member 1 |
| C7-49 | 8 | LPALASNL | H-2-Ld | 672 | Zfp467 | c.C1715T | p.P572L | zinc finger protein 467 |
| C7-50 | 8 | KPLINRHL | H-2-Ld | 864 | Snx19 | c.C2845A | p.Q949K | sorting nexin 19 |
| C7-51 | 10 | CGPLKLLVHE | H-2-Dd | 3255 | Supv3l1 | c.C710T | p.A237V | suppressor of var1, 3-like 1 (S. cerevisiae) |
| C7-52 | 8 | SPGEEMQF | H-2-Ld | 755 | Timeless | c.G1923C | p.L641F | timeless circadian clock 1 |
| C7-53 | 8 | IPSHYTEL | H-2-Ld | 631 | Atg2b | c.G1858A | p.V620I | autophagy related 2B |
| C7-54 | 9 | HLPRNSAMI | H-2-Dd | 3499 | Dcp1a | c.A1075G | p.T359A | decapping mRNA 1A |
| C7-55 | 9 | NPGAAEPPL | H-2-Ld | 586 | Chd8 | c.G797 | p.G266E | chromodomain helicase DNA binding protein 8 |
| C7-56 | 8 | SDVNAFNL | H-2-Ld | 1046 | Trabd | c.G118A | p.D40N | TraB domain containing |
| C7-57 | 9 | RAQTQPPNL | H-2-Ld | 1120 | Rbm27 | c.G1379C | p.R460P | RNA binding motif protein 27 |
n Change: nucleotide substitution and position.
a.a.Change: amino acid substitution and position.