Video 2. PP2C phosphatases and proteasomal proteases share a common conformational switch.

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DOI: 10.7554/eLife.26111.025

Shown are side-by-side displays of SpoIIE and HslV morphing from the inactive to active states. Shown on the left is the PP2C phosphatase domain of SpoIIE morphing from SpoIIE^590–827 (inactive, PDB ID 5MQH) to SpoIIE^457–827 (active, PDB ID 5UCG) as in Figure 3B. Shown on the right is HslV morphing from the HslU free structure (inactive, PDB ID 1G3K) to the HslU bound structure (active, PDB ID 1G3I) as in Figure 6D. The switch helices are colored orange and the active site residues of each protein are shown.

DOI: http://dx.doi.org/10.7554/eLife.26111.025