Table 4.
Values of various noninvasive indices and their correlations with fibrosis stages.
| Indices | METAVIR fibrosis stage | rs | p value | |||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |||
| CHB patients n (%) | 280 (28.2%) | 321 (32.4%) | 134 (13.5%) | 249 (25.1%) | ||
| Platelet count | 196 (54.5) | 189 (62.0) | 150 (72) | 117 (75) | −0.4904 | <0.0001 |
| AAR | 0.62 (0.30) | 0.67 (0.37) | 0.86 (0.37) | 1.05 (0.51) | 0.4330 | <0.0001 |
| AARPRI | 0.46 (0.32) | 0.57 (0.39) | 0.87 (0.62) | 1.32 (1.50) | 0.5610 | <0.0001 |
| APRI | 0.63 (0.80) | 0.78 (0.83) | 0.93 (1.26) | 1.03 (1.13) | 0.2259 | <0.0001 |
| FIB-4 | 1.13 (0.83) | 1.51 (1.22) | 2.17 (1.69) | 3.47 (3.55) | 0.5169 | <0.0001 |
| AP index | 3 (2.5) | 4 (4) | 6 (3) | 7 (2) | 0.5267 | <0.0001 |
| Lok index | 0.28 (0.20) | 0.34 (0.21) | 0.53 (0.31) | 0.68 (0.33) | 0.5003 | <0.0001 |
| FibroQ | 1.24 (1.13) | 1.75 (1.86) | 2.82 (2.95) | 5.54 (7.29) | 0.5333 | <0.0001 |
| mFIB-4 | 1.18 (1.12) | 1.67 (1.68) | 2.60 (2.61) | 5.00 (5.91) | 0.5297 | <0.0001 |
| CHC patients n (%) | 368 (28.7%) | 493 (38.4%) | 213 (16.6%) | 208 (16.2%) | r s | p value |
| Platelet count | 202 (74) | 165 (60) | 138 (61) | 103 (50) | −0.5614 | <0.0001 |
| AAR | 0.77 (0.39) | 0.74 (0.29) | 0.83 (0.34) | 0.99 (0.43) | 0.2365 | <0.0001 |
| AARPRI | 0.57 (0.35) | 0.68 (0.39) | 0.92 (0.63) | 1.56 (1.11) | 0.5132 | <0.0001 |
| APRI | 0.43 (0.50) | 0.90 (0.94) | 1.59 (1.67) | 1.92 (2.07) | 0.5190 | <0.0001 |
| FIB-4 | 1.29 (1.09) | 2.11 (1.72) | 3.33 (3.13) | 5.36 (4.45) | 0.6329 | <0.0001 |
| AP index | 4 (3) | 6 (3) | 7 (3) | 8 (2) | 0.5759 | <0.0001 |
| Lok index | 0.27 (0.16) | 0.36 (0.20) | 0.52 (0.28) | 0.65 (0.25) | 0.4742 | <0.0001 |
| FibroQ | 1.79 (1.65) | 2.48 (1.84) | 3.86 (3.17) | 6.80 (5.30) | 0.4980 | <0.0001 |
| mFIB-4 | 1.78 (1.75) | 2.36 (1.78) | 3.52 (2.97) | 6.18 (4.37) | 0.4866 | <0.0001 |
AAR, AST/ALT ratio; AARPRI, AAR/PLT ratio index; AP index, age-PLT index; APRI, AST/PLT ratio index; CHB, chronic hepatitis B; CHC, chronic hepatitis C; FIB-4, fibrosis index based on the four factors; FibroQ, fibrosis quotient; mFIB-4, modified FIB-4; rs: Spearman’s ranked correlation coefficients.