Table 5.
Diagnostic accuracies of noninvasive indices for predicting cirrhosis (F0–F3 versus F4).
| Index | AUROC | Cut-off | Sensitivity | Specificity | PPV | NPV | Sensitivity + Specificity-1 | Bootstrap AUROC |
|---|---|---|---|---|---|---|---|---|
| CHB | ||||||||
| Platelet | 0.8010 (0.8092–0.8346) | 140 | 65.5% | 82.9% | 56.2% | 87.8% | 48.4% | 0.7680 |
| AAR | 0.7763 (0.7111–0.8076) | 0.8 | 77.5% | 66.6% | 43.8% | 89.8% | 44.1% | 0.7400 |
| AARPRI | 0.8475 (0.8448–0.8742)* | 0.9 | 72.3% | 81.1% | 56.3% | 89.7% | 53.4% | 0.8070 |
| APRI | 0.6224 (0.7115–0.6605) | 0.7 | 74.3% | 48.4% | 32.6% | 84.9% | 22.7% | 0.6090 |
| FIB-4 | 0.8053 (0.8344–0.8362) | 2.2 | 72.7% | 75.7% | 50.1% | 89.2% | 48.4% | 0.7690 |
| Pohl score | 0.6839 (0.6309–0.7159) | 0,1 | 43.0% | 93.8% | 69.9% | 83.1% | 36.8% | 0.6990 |
| AP index | 0.8152 (0.8153–0.8445) | 6 | 75.5% | 72.5% | 48.0% | 89.8% | 48.0% | 0.7850 |
| Lok index | 0.8332 (0.8466–0.8614)* | 0.46 | 79.9% | 73.3% | 50.1% | 91.6% | 53.2% | 0.7960 |
| FibroQ | 0.8552 (0.8578–0.8868)* | 3.3 | 74.7% | 79.3% | 54.7% | 90.3% | 54.0% | 0.8110 |
| mFIB-4 | 0.8508 (0.8577–0.8773)* | 2.9 | 75.5% | 78.1% | 53.7% | 90.5% | 53.6% | 0.8070 |
| CHC | ||||||||
| Platelet | 0.8410 (0.8092–0.8729) | 130 | 78.9% | 78.4% | 41.4% | 95.1% | 57.3% | 0.8170 |
| AAR | 0.7454 (0.7111–0.7798) | 0.8 | 82.2% | 56.2% | 26.6% | 94.2% | 38.4% | 0.7210 |
| AARPRI | 0.8704 (0.8448–0.8959) | 1 | 79.3% | 78.9% | 42.1% | 95.2% | 58.2% | 0.8400 |
| APRI | 0.7473 (0.7115–0.7831) | 1.3 | 70.2% | 69.9% | 31.1% | 92.4% | 40.1% | 0.7310 |
| FIB-4 | 0.8595 (0.8344–0.8847) | 3.8 | 72.1% | 83.7% | 46.2% | 94.0% | 55.9% | 0.8310 |
| Pohl score | 0.6653 (0.6309–0.6997) | 0,1 | 40.9% | 92.2% | 50.3% | 89.0% | 33.1% | 0.6730 |
| AP index | 0.8424 (0.8153–0.8695) | 8 | 73.6% | 80.8% | 42.5% | 94.1% | 54.3% | 0.8220 |
| Lok index | 0.8715 (0.8466–0.8965)* | 0.52 | 78.9% | 81.9% | 45.7% | 95.2% | 60.7% | 0.8440 |
| FibroQ | 0.8901 (0.8578–0.9224)* | 4.3 | 78.9% | 82.9% | 47.1% | 95.3% | 61.8% | 0.8570 |
| mFIB-4 | 0.8813 (0.8577–0.9049)* | 4.0 | 78.4% | 81.5% | 45.0% | 95.1% | 59.9% | 0.8480 |
AAR, AST/ALT ratio; AARPRI, AAR/PLT ratio index; AP index, age-PLT index; APRI, AST/PLT ratio index; CHB, chronic hepatitis B; CHC, chronic hepatitis C; FIB-4, fibrosis index based on the four factors; FibroQ, fibrosis quotient; mFIB-4, modified FIB-4; NPV, negative predictive value; PPV, positive predictive value. *p > 0.05 compared with mFIB-4, p < 0.05 for all other indexes compared with mFIB-4.