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. 2017 Jun 12;7:3310. doi: 10.1038/s41598-017-02987-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of IL-37 on the Th1/Th2/Th17/Treg paradigm in vitro. (A) Flow cytometry results of (CD4+IFN-γ+), Th2 (CD4+IL-4+), Th17 (CD4+IL-17+), and Tregs (CD4+CD25+FOXP3+) are shown. Results of statistical analysis of Th1 cells, Th2 cells, Th17 cells, and Tregs. (B) Results of statistical analysis of the cytokine levels in the cultured supernatant. The data represent 3 experiments in each group. Values are presented as the means ± SEM. *p < 0.05, and **p < 0.01.