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. 2017 Jun 12;7:3303. doi: 10.1038/s41598-017-03015-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AgNPs or AuNPs levels in animal tissues (a–c), blood (d) and feces (e) as indicators of inorganic NPs biodistribution, circulation and elimination at serial time points. These results show mean and standard deviation, n = 5. a Exhibits the contents of AgNPs or AuNPs in the liver and spleen at both time points, b and c exhibit the contents of AgNPs or AuNPs in the other organs at both time points, respectively. Day −25 to day 0 are the time interval during which the NPs were administered.