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. 2017 Jun 12;7:3228. doi: 10.1038/s41598-017-03417-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Selectivity of new inhibitors for HDAC isozymes. The phylogenetic tree of HDAC isozymes, class I, class IIa, class IIb and class IV HDAC are grouped according to sequence homology and shaded as pink, blue, green and yellow, respectively. The red circles represent IC₅₀ values as observed in Table 2, with the largest circle indicating the lowest IC₅₀ values.