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Structures of six compounds and SAHA and their IC50 values (µM) of HDAC4 inhibitory activity.
| Compound | Group | IC50 | Structure |
|---|---|---|---|
| A4291 | Catechol | 24.7 |
|
| A159452 | Catechol | 4.4 |
|
| A226640 | Sulfone | 14.9 |
|
| A640973 | Sulfone | 17.4 |
|
| A364365 | Sulfone | 2.5 |
|
| A363007 | Phosphonic acid | 4.1 |
|
| SAHA | Hydroxamic acid | >40 |
|
