Table 5.
Comparing sedative drug use and cumulative administered dose among patients with and without delayed intracranial conduction time
| Variables | All patients | SSEP’s P14–N20 (ICCT) | BAEP’s III–V (IPCT) | ||||
|---|---|---|---|---|---|---|---|
| Delayed | Non delayed | *p value | Delayed | Non delayed | *p value | ||
| Number of patients—n (%) | 86 (100) | 39 (45) | 47 (55) | 15 (17) | 71 (83) | ||
| RASS—median (IQR) | −5 (−5 to −4.2) | −5 (−5 to −5) | −5 (−5 to −4) | 0.003 | −5 (−5 to −4) | −5 (−5 to −5) | 0.45 |
| Body temperature (°C)—mean (SD) | 36. (1.0) | 36.7 (1.0) | 36.4 (0.9) | 0.10 | 36.5 (1.1) | 36.6 (1.0) | 0.67 |
| Sedative drugs used | |||||||
| Midazolam—n (%) | 79 (92) | 36 (42) | 43 (50) | 0.89 | 14 (18) | 65 (82) | 0.82 |
| Sufentanil—n (%) | 79 (92) | 37 (43) | 42 (49) | 0.36 | 15 (19) | 64 (81) | 0.21 |
| Propofol—n (%) | 9 (10) | 2 (2) | 7 (8) | 0.14 | 1 (11) | 8 (89) | 0.60 |
| Sedative drugs’ cumulative doses | |||||||
| Midazolam (mg/kg)—median (IQR) | 5 (5 to 8) | 5 (5 to 9) | 5 (5 to 8) | 0.74 | 5 (4.2 to 9) | 5 (5 to 8) | 0.54 |
| Sufentanil (µg/kg)—median (IQR) | 20 (10 to 30) | 20 (10 to 30) | 20 (10 to 30) | 0.70 | 20 (10 to 25) | 20 (10 to 30) | 0.63 |
| Propofol (mg/kg)—median (IQR) | 10 (0 to 40) | 3 (1.5 to 6) | 20 (1.5 to 85) | 0.22 | 3 (3 to 3) | 15 (0 to 55) | 0.40 |
| Abnormal brain imaging—n (%) | 34/59 (58) | 18/34 (53) | 16/34 (47) | 0.08 | 5/34 (15) | 29/34 (85) | 0.46 |
| Focal brain injury—n (%) | 11 (32) | 6 (55) | 5 (45) | 0.96 | 1 (9) | 10 (91) | 0.72 |
| Diffuse brain injury—n (%) | 23 (68) | 12 (52) | 11 (48) | 0.78 | 4 (17) | 19 (83) | 0.66 |
* Mann–Whitney test