Table 5.

Outcomes of combining subcutaneous insulin with insulin infusion.

Trial	Arms	Outcomes of IV insulin infusion vs. IV insulin infusion plus glargine retrospectively	p-Value
Hsia et al.—prospective randomised study (43)	IV Insulin infusion (n = 31) vs. IV insulin infusion plus glarginea (n = 30)	BGL > 10 mmol/L at 12 h follow-up: 29 (93.5%) vs. 10 (33.3%)	<0.001
		Hypoglycemic events: 9.6 vs. 0.0%	Not stated
Doshi et al.—pilot prospective RCT (44)	IV insulin infusion (n = 20) vs. IV insulin infusion plus glargine (n = 20)	Time to closure of anion gap (TCAG): 11.6 (±6.4) vs. 10.2 h (±6.8)	0.63
		Length of hospital stay: 4.6 (± 3.6) vs. 3.9 days (± 3.4)	0.66
		Number of hypoglycaemic events: 3 (15%) vs. 2 (10%)	1.0

^aGlargine dosed at 0.25 U/kg per body weight.

RCT, randomised controlled trial.