Table 7.
Impact on outcomes when treating diabetic ketoacidosis according to protocol.
| Study | Arms | End points | Findings |
p-Value |
|---|---|---|---|---|
| Protocol vs. non-protocol arms respectively | ||||
| Thuzar et al.—retrospective study (11) | Protocol (n = 35) No protocol (n = 36) |
Mean length of hospitalisation | 37.9 vs. 49.2 h | 0.01 |
| Mean time to normalisation of serum bicarbonate | 15.1 vs. 24.6 h | 0.01 | ||
| Incidences of hypokalaemia | 28.6 vs. 52.8% | 0.038 | ||
| Incidence of hypoglycaemia | 8.6 vs. 28% | 0.036 | ||
| Hara et al.—retrospective review (12) | Protocol (n = 113) Non-protocol (n = 143) |
Mean difference in time to resolution | −9.2 h (95% CI: 4.7–13.7) | <0.01 |
| Frequency of hypoglycaemia | 8 vs. 11.2% | 0.259 | ||
| Frequency of hypokalaemia | 30.1 vs. 32.3% | 0.413 | ||
| Mean difference in length of hospital stay | −2.04 days (95% CI: 0.61–3.46) | 0.005 | ||