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AZD1446 has no effect on striatal DA efflux via in vivo microdialysis (A) WT mice showed no significant increase of striatal DA when AZD1446 was systemically injected at 0.25 mg/kg, 0.5 mg/kg and 0.75 mg/kg (ip). (B) WT mice showed no significant increase in striatal DA when AZD1446 was striatally infused at 30 μM, 300 μM or 1 mM. (C) Neither WT or DYT1 KI mice showed a significant increase in DA efflux with 300 μM AZD1446 added to artificial cerebrospinal fluid (aCSF).
