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. 2017 Jun 13;11:43. doi: 10.3389/fnsys.2017.00043

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Copyright © 2017 Zimmerman, Eskow Jaunarajs, Meringolo, Rizzo, Santoro, Standaert and Pisani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AZD1446 effects on intrinsic membrane and synaptic properties of spiny projection striatal neurons (SPNs), and paired pulse ratio (PPR). (A,B) Dose-response curves of input resistance (IR) and resting membrane potential (RMP) after bath application of increasing concentrations of AZD1446 (0.1–30 μM). Note, at higher concentrations, a slight depolarization and an increase of membrane resistance of recorded neurons. (C) Dose-response curve of excitatory postsynaptic potentials (EPSPs) amplitude (expressed as % of inhibition) measured at increasing doses of AZD1446 (0.01–10 μM). AZD1446 dose-dependently inhibits corticostriatal EPSP in both genotypes. Each data point represents the mean of at least five independent observations. (D) Paired pulse facilitation (50 ms interstimulus interval). Plot does not show significant difference between WT and DYT1 KI mice after bath application of AZD1446 (1 μM; ANOVA p > 0.05).