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. 2017 Jun 13;11:43. doi: 10.3389/fnsys.2017.00043

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Copyright © 2017 Zimmerman, Eskow Jaunarajs, Meringolo, Rizzo, Santoro, Standaert and Pisani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AZD1446 does not produce statistically significant changes on the firing frequency of striatal cholinergic interneurons (ChIs). (A) Plots show firing frequency of ChIs (expressed as % of baseline) after bath-perfusion of two different doses of AZD1446 (1 μM and 10 μmM, 2 min). No significant differences were found in two genotypes at two tested doses (ANOVA p > 0.05). (B) Representative traces of spontaneous firing activity of ChIs recorded in a cell-attached patch clamp configuration, before and after bath application of AZD1446 (1 μM, 2 min).