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Effect of a single fast perfusion application of AZD1446 on firing frequency of striatal ChIs. (A) Summary bar chart of the effect of a single delivered puff of AZD1446 (1 μM, 500 ms). AZD1446 does not produce any significant effect on firing frequency of ChIs (ANOVA p > 0.05). (B) Sample traces showing the firing rate recorded after fast application of AZD1446 (1 μM, 500 ms), respectively in WT and DYT1 KI mice. Red arrow shows the release of puff.
