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AZD1446 increases the firing rate of nigral dopaminergic cells. (A) Plot shows normalized firing frequency of dopaminergic neurons after bath perfusion of AZD1446 (10 μM, 4 min). Note the increase of firing rate in both genotypes (t-test paired *p < 0.05). (B) Representative traces of firing frequency of nigral cells in control condition (above) and after bath perfusion of AZD1446 (below).
