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. 2017 Jun 13;11:43. doi: 10.3389/fnsys.2017.00043

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Copyright © 2017 Zimmerman, Eskow Jaunarajs, Meringolo, Rizzo, Santoro, Standaert and Pisani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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α₄β₂ nicotinic receptor antagonist dihydro-beta-erythroidine (DHβE) blocks AZD1446 effect on nigral cells recording. (A) Plot of normalized firing rate of nigral dopaminergic neurons. Pre-incubation of α₄β₂ nicotinic receptor antagonist DHβE (3 μM) blocks the effect of AZD1446 (10 μM, 4 min), (t-test unpaired p > 0.05). (B) Representative traces of firing frequency after pre-incubation of DHβE (above) and after added AZD1446 (below).