Table 1.
Difference between resistance, tolerance and persistence.
| Resistance | Tolerance | Persistence | |
|---|---|---|---|
| Heterogeneity | No | No | Yes |
| Inheritability | Yes | Yes or No | No |
| MIC | MICR > MICS | MICT = MICS | MICP = MICS |
| MDK | – | MDK99T> MDK99S | MDK99P = MDK99S MDK99.99P > MDK99.99S |
| Form | – | 1) Tolerance by slow growth (High MDK in stationary and exponential inocula) 2) Tolerance by lag (High MDK only in stationary inocula) |
1) Time-dependent persisters a) Persistence by slow growth b) Persistence by lag |
| 2) Dose-dependent persisters |
MIC, the minimum inhibitory concentration; MDK, the minimum duration for killing; MDK99, MDK for 99% of bacterial cells in the population; MDK99.99, MDK for 99.99% of bacterial cells in the population; S, Susceptible; R, Resistant; T, Tolerant; P, Persistent.