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. 2017 Jun 13;8:684. doi: 10.3389/fimmu.2017.00684

Figure 3.

Figure 3

Monophosphoryl lipid A (MPLA) incorporation in peptide-based poly(lactic-co-glycolic) acid (PLGA) nanoformulations further enhanced the maturation of dendritic cells (DCs) from HLA A2.1 transgenic mice. DCs were cultured for 24 h upon stimulation with the mix of PLGA-chCPAp-MPLA, PLGA-chH1p-MPLA, and PLGA-KMP-11p-MPLA nanoformulations (mix B), the mix of soluble chimeric peptides with MPLA adjuvant (mix E), or PLGA nanoparticles with MPLA encapsulated. (A) Representative histogram plots of CD40, CD80, CD86, major histocompatibility complex (MHC) class I, and class II molecules levels. (B) Diagram demonstrating the percentage (%) of DCs expressing the co-stimulatory and MHC class I and class II molecules. (C) Diagram demonstrating the mean fluorescence index (MFI) of DCs expressing the co-stimulatory and MHC class I and class II molecules. Results are expressed as the mean ± SD of three independent experiments. Significant differences are indicated by *p < 0.05, **p < 0.01, or ***p < 0.001.