Table 1.

CTL formulas.

No.	CTL Formulas	References
1	(PI3K = 0∧FOXO = 0∧mTORC2 = 0, ∧Akt = 0∧mTORC1 = 0∧PTEN = 0) →, (EX(EF(PI3K = 0∧FOXO = 0∧mTORC2 = 0∧Akt = 0∧mTORC1 = 0)))	Zoncu et al., 2011
2	(PTEN = 1∧FOXO = 1∧Akt = 0∧PI3K = 1∧mTORC1 = 1∧mTORC2 = 1) → (EF(AG(Akt = 1∧PTEN = 0∧FOXO = 0∧mTORC1 = 1∧mTORC2 = 1∧PI3K = 1)))	Carracedo and Pandolfi, 2008; Chen et al., 2010; Zoncu et al., 2011; Laplante and Sabatini, 2012
3	(PI3K = 1∧FOXO = 0∧Akt = 1∧mTORC1 = 1) → (EF(AG(Akt = 1∧FOXO = 0∧PTEN = 0)))	Carracedo and Pandolfi, 2008; Zoncu et al., 2011

These CTL formulas are used in SMBioNet tool to infer the set of logical parameters. Formula 1 is designed to observe homeostasis while the other two formulas are used for observing stable steady state(s).