Table 2.
Selection of logical parameters.
| Parameter | Resource(s) | Range of Values | Selected Parameters |
|---|---|---|---|
| KPI3K | {} | 0 | 0 |
| KPI3K | {mTORC1} | 0,1 | 1 |
| KPI3K | {PTEN} | 0,1 | 1 |
| KPI3K | {mTORC1, PTEN} | 0,1 | 1 |
| KPTEN | {} | 0 | 0 |
| KPTEN | {PI3K} | 1 | 1 |
| KmTORC2 | {} | 0 | 0 |
| KmTORC2 | {FOXO} | 0,1 | 1 |
| KmTORC2 | {mTORC1} | 1 | 1 |
| KmTORC2 | {PI3K} | 0,1 | 1 |
| KmTORC2 | {FOXO, mTORC1} | 1 | 1 |
| KmTORC2 | {FOXO, PI3K} | 0,1 | 1 |
| KmTORC2 | {mTORC1, PI3K} | 1 | 1 |
| KmTORC2 | {FOXO, mTORC1, PI3K} | 1 | 1 |
| KAkt | {} | 0 | 0 |
| KAkt | {mTORC2} | 0 | 0 |
| KAkt | {PI3K} | 0 | 0 |
| KAkt | {mTORC2, PI3K} | 1 | 1 |
| KmTORC1 | {} | 0 | 0 |
| KmTORC1 | {Akt} | 0,1 | 0 |
| KmTORC1 | {FOXO} | 1 | 1 |
| KmTORC1 | {Akt, FOXO} | 1 | 1 |
| KFOXO | {} | 0 | 0 |
| KFOXO | {Akt} | 1 | 1 |
| KFOXO | {mTORC1} | 0 | 0 |
| KFOXO | {Akt, mTORC1} | 1 | 1 |
This table describes the ranges of logical parameter values. Some parameters are fixed to single values 0 or 1 based on biological observations. The last column lists one of the eight selected parameter sets generated by SMBioNet.