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. 2017 Jun 13;8:372. doi: 10.3389/fphar.2017.00372

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Copyright © 2017 Yu, Chen and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic diagram representing the regulation of hepatic LDLR by statins. (1) Statins up-regulate LDLR via SREBP2. (2) SREBP2 also increases transcription of PCSK9 to degrade LDLR. (3) Cellular cholesterol accumulation may activate LXR, which up-regulates Idol to degrade LDLR.