Table 1.
Characteristics of Study Cohort.
| Variablea | Value |
|---|---|
| Age, yr | 6.3 (1.5-13.8) |
|
Sex, n (%)
Male Female |
88 (55) 72 (45) |
|
Race, n (%)
White Black Asian Unknown |
76 (48) 53 (33) 4 (3) 27 (16) |
|
Comorbid Conditions, n (%)
None One Two Three or more Oncologic comorbid condition, n (%) Stem cell transplant, n (%) |
69 (43) 62 (39) 18 (11) 11 (7) 33 (21) 6 (4) |
|
Location of Sepsis Recognition, n (%)
Emergency Department Inpatient Ward Pediatric Intensive Care Unit Periop Complex |
83 (52) 44 (28) 31 (19) 2 (1) |
| Pediatric Index of Mortality 2 | 1.8 (0.9-4.5) |
| Pediatric Risk of Mortality III score | 8 (3-15) |
|
Baseline laboratory valuesb
White blood cell count (1,000/μL) Hemoglobin (g/dL) Platelets (1,000/μL) Creatinine (mg/dL) International normalized ratio Lactate (mmol/L) |
8.3 (3.8-14.3) 10.2 (8.8-12) 211 (76-340) 0.3 (0.2-0.5) 1.24 (1.1-1.4) 1.8 (1.2-2.7) |
|
Compliance with initial resuscitation goals, n (%)
Blood culture drawn before antimicrobial Initial Antimicrobial ≤ 1hr Initial Antimicrobial ≤ 3hr Appropriate antimicrobial ≤ 1hr Appropriate antimicrobial ≤ 3hr Initial fluid bolus ≤ 20 min Initial fluid bolus ≤ 60 min Lactate measured |
129 (81) 35 (22) 98 (61) 24 (15) 84 (52.5) 33 (20) 60 (37.5) 143 (89) |
|
Sepsis related therapies
Central venous catheter, n (%) Required vasoactive infusion, n (%) Required mechanical ventilation, n (%) Required extracorporeal membrane oxygenation, n (%) |
107 (67) 101 (63) 70 (44) 2 (<1) |
a
Median values (interquartile range), unless indicated.
b
Values at or closest to time of sepsis recognition.
Total patients n=160.