Table 2.
Clinicopathological Features of Malignant Mesotheliomas in the Screening Cohort
| Characteristics | Localization
|
||
|---|---|---|---|
| Peritoneal n = 13 (52%) |
Thoracic n = 12 (48%) |
Total n = 25 |
|
| Age, years; median (range) | 30 (7–40) | 33 (8–38) | 31 (7–40) |
| Sex, n (%) | |||
| Male | 10* (77) | 4 (33) | 14 (56) |
| Female | 3 (23) | 8 (67) | 11 (44) |
| Asbestos exposure, n (%) | |||
| None | 6 (46) | 7 (58) | 13 (52) |
| Potential Indirect | 0 (0) | 3 (25) | 3 (12) |
| N/A | 7 (54) | 2 (17) | 9 (36) |
| Smoking | |||
| Never smoker | 3 (31) | 2 (17) | 6 (24) |
| Light smoker | 0 | 3 (25) | 3 (12) |
| Heavy smoker | 1(8) | 4 (33) | 5 (20) |
| N/A | 8 (61) | 3 (25) | 11 (44) |
| Morphology | |||
| Epithelioid | 13 (100) | 11 (92) | 24 (96) |
| Sarcomatoid | 0 | 0 | 0 |
| Biphasic | 0 | 1 (8) | 1 (4) |
| BAP1 IHC, n (%) | |||
| Retained | 6 (46) | 9 (75) | 15 (60) |
| Loss | 0 | 3 (25) | 3 (12) |
| Failure/N/A | 1/6 (54) | 0/0 | 7 (28) |
| EWSR1/FUS-ATF1 fusion, n (%) | |||
| Positive | 3 (23) | 1 (8) | 4 (16) |
| Negative | 10 (77) | 11 (92) | 21 (84) |
*
male: female ratio statistically significant between thoracic and peritoneal localization (p = 0.047); N/A: not available; IHC, immunohistochemistry; FISH, fluorescence in situ hybridization