Table 1.
Characteristics of study populations
| Cohort | N | Nexposed (%) | Age, y (SD) | Female, N (%) | QT interval, ms (SD) | JT interval, ms (SD) | QRS interval, ms (SD) |
|---|---|---|---|---|---|---|---|
| European Ancestry | |||||||
| AGES | 2 587 | 64 (2.5) | 75 (4.7) | 925 (64) | 406 (34) | 316 (33) | 90 (10) |
| ARIC | 8 597 | 379 (4.4) | 54 (5.7) | 4 453 (53) | 399 (29) | 308 (29) | 91 (10) |
| CHS | 3 055 | 280 (9.2) | 72 (5.3) | 1 880 (63) | 414 (32) | 321 (30) | 88 (10) |
| Health ABC | 1 441 | 81 (5.6) | 74 (2.8) | 714 (49) | 414 (32) | 324 (32) | 90 (11) |
| MESA | 2 256 | 71 (3.1) | 62 (10.1) | 1 156 (52) | 412 (29) | 320 (29) | 93 (9) |
| NEO | 5 366 | 94 (1.8) | 56 (5.9) | 2 521 (47) | 406 (29) | 313 (29) | 93 (10) |
| PROSPER | 4 555 | 243 (5.3) | 75 (3.3) | 2 445 (47) | 414 (36) | 320 (35) | 94 (11) |
| Rotterdam 1 | 4 805 | 216 (4.5) | 69 (8.6) | 2 891 (60) | 397 (29) | 300 (28) | 97 (11) |
| Rotterdam 2 | 1 889 | 84 (4.4) | 65 (7.6) | 1 070 (57) | 403 (28) | 305 (28) | 98 (11) |
| WHI GARNET | 3 943 | 304 (7.7) | 66 (6.8) | 3 642 (100) | 400 (32) | 314 (31) | 86 (9) |
| WHI MOPMAP | 1 324 | 36 (2.7) | 63 (6.6) | 1 224 (100) | 402 (30) | 316 (30) | 86 (8) |
| WHIMS | 5 184 | 243 (4.7) | 69 (6.0) | 4 811 (100) | 401 (30) | 315 (30) | 86 (9) |
| Total | 45 002 | 2 095 (4.7) | |||||
| African American | |||||||
| ARIC | 2 191 | 213 (9.7) | 53 (5.8) | 1 322 (62) | 400 (33) | 310 (32) | 90 (10) |
| CHS | 707 | 141 (20.0) | 73 (5.6) | 447 (65) | 409 (35) | 317 (36) | 88 (11) |
| Health ABC | 1 020 | 111 (10.9) | 73 (2.9) | 588 (58) | 411 (35) | 322 (34) | 88 (11) |
| JHS | 2 122 | 117 (5.5) | 50 (11.8) | 1 244 (61) | 410 (30) | 319 (30) | 92 (1) |
| MESA | 1 464 | 135 (9.2) | 62 (10.0) | 796 (54) | 410 (32) | 319 (31) | 91 (10) |
| WHI SHARe | 4 227 | 450 (10.6) | 61 (6.8) | 3 860 (100) | 401 (34) | 316 (33) | 85 (9) |
| Total | 11 731 | 1 167 (9.9) | |||||
| Hispanic/Latino | |||||||
| HCHS/SOL | 12 024 | 518 (4.3) | 46 (13.8) | 7 155 (60) | 416 (28) | 325 (29) | 91 (10) |
| MESA | 1 316 | 134 (10.2) | 61 (10.3) | 681 (52) | 409 (30) | 318 (30) | 91 (10) |
| WHI SHARe | 1 784 | 142 (7.9) | 60 (6.4) | 1 627 (100) | 402 (30) | 316 (30) | 86 (9) |
| Total | 15 124 | 794 (5.2) | |||||
| Total, all ancestries | 71 857 | 4 056 (5.6) | |||||
. ms = milliseconds, SD = standard deviation, y = years. Study abbreviations: AGES = Age, Gene/Environment Susceptibility – Reykjavik Study, ARIC = Atherosclerosis Risk in Communities Study, CHS = Cardiovascular Health Study, Health ABC = Health, Aging, and Body Composition Study, HCHS/SOL = Hispanic Community Health Study/Study of Latinos, JHS = Jackson Heart Study, MESA = Multi-Ethnic Study of Atherosclerosis, NEO = Netherlands Epidemiology of Obesity, PROSPER = Prospective Study of Pravastatin in the Elderly at Risk, Rotterdam 1 = first cohort of the Rotterdam Study, Rotterdam 2 = second cohort of the Rotterdam study, WHI GARNET = Women’s Health Initiative Genome-wide Association Research Network into Effects of Treatment, WHI MOPMAP = Women’s Health Initiative Modification of Particulate Matter-Mediated Arrhythmogenesis in Populations, WHI SHARe = Women’s Health Initiative SNP Health Association Resource, WHIMS = Women’s Health Initiative Memory Study.