Table 2.
Summary of significant sulfonylurea-SNP interaction associations with QT, JT, and QRS intervals from ancestry-specific GWAS meta-analyses (P < 5 x 10−8)
| Lead SNP | Chr:position (hg19) | Nearest gene | Race | Studies | Min/alt alleles | MAF | Effect | SE | P | Function | Other GWAS | Coding | eQTL (P<5x10−8) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| QT interval | |||||||||||||
| rs9966832 | 18:23405188 | SS18 | EA | 3 | G/A | 0.03 | −10.4 | 1.9 | 2.3E-08 | Intergenic | Periodontitis66 | ||
| rs830233 | 5:165403746 | AA | 4 | A/G | 0.05 | −16.3 | 2.3 | 2.5E-12 | Intergenic | ||||
| JT interval | |||||||||||||
| rs1890262 | 1:62114402 | TM2D1,NFIA | EA | 2 | A/G | 0.03 | 14.9 | 2.6 | 1.8E-08 | Intergenic | |||
| rs12468579 | 2:191832264 | GLS,STAT1 | AA | 6 | G/A | 0.49 | 4.1 | 0.8 | 4.5E-08 | Intergenic | GLS60–63, MFSD660 | ||
| rs1478173 | 3:162276405 | AA | 2 | C/A | 0.03 | −15.0 | 2.1 | 1.0E-12 | Intergenic | ||||
| rs17281245 | 4:182635289 | TENM3 | AA | 5 | C/T | 0.06 | 8.8 | 1.5 | 5.4E-09 | Intergenic | |||
| rs7713675 | 5:28750307 | LSP1P3 | AA | 4 | C/T | 0.05 | −12.2 | 2.1 | 9.8E-09 | Intergenic | |||
| QRS interval | |||||||||||||
| rs7595140 | 2:71551621 | ZNF638,PAIP2B | EA | 4 | G/C | 0.03 | −5.7 | 1.0 | 3.8E-08 | Intergenic | |||
EA = European ancestry, AA = African American, HA = Hispanic/Latino ancestry, MAF = minor allele frequency, SE = standard error. Studies = number of cohorts contributing to ancestry-specific analysis. Other GWAS = phenotypes associated with lead SNP (P < 5 x 10−8) in other genome-wide association studies. Coding = lead SNP in linkage disequilibrium (r2 > 0.8) with a protein coding variant. eQTL = transcripts associated with SNPs in linkage disequilibrium (r2 > 0.8) with lead SNP.