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. Author manuscript; available in PMC: 2018 Mar 23.
Published in final edited form as: Mol Psychiatry. 2016 Dec 13;23(4):904–913. doi: 10.1038/mp.2016.219

Figure 3. BDNF-Val66Met mice exhibit a unique translational profile in response to stress.

Figure 3

A) Venn diagram showing that similar genes were differentially expressed in both the BDNFMet/+ and BDNFMet/Met mice compared to WT. B,C) Venn diagram illustrating that BDNFMet/+ mice exposed to CRS exhibited numerous unique expression changes that were not present in WT mice after CRS. D) Heatmap of expression level changes in GR-regulated transcripts revealed i) genes increased by CRS in WT mice that did not show the same change with CRS in BDNFMet/+, ii) genes increased by CRS in BDNFMet/+ that were primarily unchanged with stress in WT mice and iii) genes that were different by genotype at baseline and changed by stress in BDNFMet/+.