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. 2016 Dec 13;23(2):231–239. doi: 10.1038/mp.2016.222

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Properties of Na_V1.7^WT and Na_V1.7^M932L/V991L expressed in cultured cortical neurons. (a) Representative set of sodium current traces from cortical neurons expressing Na_V1.7^WT and Na_V1.7^M932L/V991L. (b) Mean current–voltage (I–V) relationships of peak currents. (c) Voltage dependence of activation (right curves) and the voltage dependence of steady-state fast inactivation. (d) Mean normalized currents during 100 depolarizations to 0 mV at 50 Hz. Na_V1.7^WT, n=4, Na_V1.7^M932L/V991L, n=5. (e and f) Firing of cortical neurons expressing Na_V1.7^WT and Na_V1.7^M932L/V991L. (e) Representative firing in response to 100 pA depolarizing current injection. (f) Average number of action potentials (AP) in response to 1 s depolarizing current injection at the indicated intensity. Na_V1.7^WT, n=7, Na_V1.7^M932L/V991L, n=7.