Table 1.

Review of current literature in chronological order on the changes in memory and insulin signaling with various treatments in SAMP8 mice. Other than memory improvements with treatment, molecular key findings related to insulin are listed.

Authors	Year	Treatment	Key Finding
1 Banks et al	2000	Insulin transport	No change in insulin BBB transport
2 Lin et al	2013	Asiaticoside	Increased levels of IDE mRNA
3 Kuang et al	2014	Ligustilide	Klotho upregulation and inhibition of insulin signaling
4 Adler et al	2014	Pramlintide	Decreased oxidative stress
5 Armbrecht et al	2015	Ap protein precursor antisense	Changes in insulin signaling pathways
6 Zhou et al	2015	Tetrahydroxystilbene glucoside (TSG)	Decreased levels of insulin and receptors
7 Tong/Yan et al	2015	Acarbose	Prevention of decline in insulin and receptors
8 Chen et al	2015	1-deoxynojirimycin (DNJ)	Prevention of decline in insulin and receptors