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. 2017 Jun 13;5:17012. doi: 10.1038/boneres.2017.12

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Orientation of joint space on an ultrasound image. A 3-month-old wild-type C57BL/6 male mouse was used. (a) An ultrasound B-mode image of a mouse knee joint. (b) Outlined joint space (solid green), tibia, and femur on the ultrasound B-mode image. (c) Alcian blue/Orange G (ABOG)-stained knee section with outlined joint space detected by ultrasound. (d) Illustration shows 3D reconstruction of join space derived from a stack of ultrasound B-mode images.