Table 1.
Mitochondria-targeted molecular imaging agents for myocardium in cardiac function.
| Radiotracers | Modality | Location/target | Assessment | In preclinic | In clinic | QL & QT |
|---|---|---|---|---|---|---|
| 99mTc-tetrofosmin | SPECT | Inner membrane | MBF | Yes | QL | |
| 99mTc-MIBI | SPECT | Inner membrane | MBF | Yes | QL | |
| 99mTc-TMEOP | SPECT | Inner membrane | MBF | Yes | QL | |
| 99mTc-N-MPO | SPECT | Inner membrane | MBF | Yes | QL | |
| 99mTc-N-DBODC5 | SPECT | Inner membrane | MBF | Yes | QL | |
| 123I-BMIPP | SPECT | Fatty acid oxidation | Metabolic | Yes | QL | |
| 123I-CMICE-013 | SPECT | Complex I | MC-I receptor | Yes | QT | |
| 123I-ZIROT | SPECT | Complex I | MC-I receptor | Yes | QT | |
| 18F-BCPP-EF | PET | Complex I | MC-I receptor | Yes | QT | |
| 18F-FDHR | PET | Complex I | MBF | Yes | QT | |
| 18F-FP2OP | PET | Complex I | MC-I receptor | Yes | QT | |
| 18F-FP1OP | PET | Complex I | MC-I receptor | Yes | QT | |
| 18F-FP3OP | PET | Complex I | MC-I receptor | Yes | QT | |
| 18F-Flurpiridaz | PET | Complex I | MC-I receptor | Yes | QT | |
| 18F-RP1003 | PET | Complex I | MC-I receptor | Yes | QT | |
| 18F-RP1004 | PET | Complex I | MC-I receptor | Yes | QT | |
| 18F-RP1005 | PET | Complex I | MC-I receptor | Yes | QT | |
| 18F-FBnTP | PET | Inner membrane | MBF/perfusion | Yes | QL | |
| 18F-FETM | PET | Inner membrane | MBF/perfusion | Yes | QL | |
| 18F-FERhB | PET | Inner membrane | MBF/perfusion | Yes | QL | |
| 18F-FMBTP | PET | Inner membrane | MBF/perfusion | Yes | QL | |
| 18F-mFMBTP | PET | Inner membrane | MBF/perfusion | Yes | QL | |
| 18F-TPP | PET | Inner membrane | MBF/perfusion | Yes | QL | |
| 18F-FPTP | PET | Inner membrane | MBF/perfusion | Yes | QL | |
| 18F-FTPP | PET | Outer membrane | MBF/perfusion | Yes | QL | |
| 18F-FTHA | PET | Fatty acid oxidation | Metabolic | Yes | QL | |
| 18F-FTP | PET | Fatty acid oxidation | Metabolic | Yes | QL | |
| 18F-FTO | PET | Fatty acid oxidation | Metabolic | Yes | QL |
MBF, myocardial blood flow; PET, positron emission tomography; SPECT, single photon emission tomography; QL, qualifiable; QT, quantifiable.