Table 1.

Deregulated miRNAs, their roles, targets, and expression in both alveolar and embryonic RMS.

Name	miRNA level in RMS relative to normal human myoblasts		Target genes in RMS	Function	Reference
	Alveolar	Embryonal
miR-1	Down	Up	CCND2, cMET, PAX3	Tumor suppressor	[35, 36]
miR-24	Down	Down	—	—	[76]
miR-26a	Down	Down	Ezh2	Tumor suppressor	[36, 37, 76]
miR-27a	Down	Down	PAX3	Tumor suppressor	[36, 76]
miR-29	Down	Down	CCND2, PAX3, CCND2	Tumor suppressor	[36, 41]
miR-133a	Down	Down	TPM4	Tumor suppressor	[36, 76, 77]
miR-133b	Down	Down	—	Tumor suppressor	[36, 75]
miR-181	Down	Down	HOXA11	Tumor suppressor	[36, 42]
miR-183	Up	—	EGR1, PTEN	Oncogene	[36, 77]
miR-203	Down	Down	p63, LIF	Tumor suppressor	[43, 76]
miR-206	Down	Down	CCND2, cMET, PAX3	Tumor suppressor	[35, 75, 77]
miR-214	Down	Down	N-RAS	Tumor suppressor	[38, 44]
miR-301	Up	Up	—	Oncogene	[76]
miR-378a	Down	Down	IGF1R	Tumor suppressor	[45]
miR-450b	Down	Down	ENOX2, PAX9	Tumor suppressor	[44, 78]
miR-485	Up	—	NF-YB	Oncogene	[79]