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. 2017 May 22;114(23):6116–6121. doi: 10.1073/pnas.1619424114

Fig. S4.

Fig. S4.

MPIOs-αP-selectin enhanced MRI is compatible with longitudinal follow up of disease activity. (A) Experimental design of the longitudinal study of the MPIO-αP-selectin stall after i.v. injection. (B) Representative high-resolution T2*-weighted images after MPIOs-αP-selectin injection at indicated times (Top, +10 min; Middle, +8 h; Bottom, +24 h). (C) Corresponding signal void quantification of the caudal spinal cord (n = 4 per group). #P < 0.05. (D) Corresponding signal void quantification of the rostral spinal cord (n = 4 per group). #P < 0.05. (E) Representative axial and sagittal T2*-weighted images of the spinal cord of PLP-induced EAE mice during first relapse. (F) Representative axial and sagittal T2*-weighted images after MPIOs-αP-selectin of the same PLP-induced EAE mice (during recovery). (G) Corresponding signal void quantification of the caudal and rostral spinal cord (n = 3 per group). #P < 0.05.