Fig. 2.

Structural comparison of the DPF2 and DPF3b tandem PHD finger domains. (A) A ribbon representation of DPF2^PHD (Left, colored as in Fig. 1A), DPF3b^PHD•H3K14^Ac (Center, colored in gray, PDB ID code 2KWJ) (16), and a superposition of the two, based on alignment of PHD2s (Right). The hinge between PHD1 and PHD2 is indicated by an arrow. (B) Surface representations of the DPF3b^PHD•H3K14^Ac (Upper, PDB ID code 2KWJ) and the DPF3b^PHD•H4K16^Ac (Lower, PDB ID code 2KWN) solution NMR structures (16). Boxes show a cartoon representation of the indicated binding sites superposed with our DPF2^PHD crystal structure. Residues constituting the bipartite histone-recognition motif are shown in stick representation.