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. 2017 May 3;114(23):E4549–E4555. doi: 10.1073/pnas.1620486114

Table S1.

List of parameters used in the model

Model parameter Description Value Source
Ep FA plaque modulus ∼0.05 kPa Estimated from Fisher et al. (41)
EECM ECM modulus ∼0–20 kPa Typical value for ECM modulus
ki Integrin stiffness 5 pN/nm Estimated from Fisher et al. (41)
En Nucleus modulus ∼5–10 kPa Caille et al. (42)
K Stiffness of the cytoskeleton ∼1 kPa Chiron et al. (43)
ρ0 Initial myosin motor density ∼0.5 kPa Wang et al. (44)
β Chemo-mechanical coupling parameters related to the molecular mechanisms that regulate the engagement of motors 2.77×103 Pa Shenoy et al. (33)
α Chemo-mechanical coupling parameters related to the molecular mechanisms that regulate the stress-dependent signaling pathways 1.91×103 Pa Shenoy et al. (33)
h Thickness of FA plaque 0.1μm Kanchanawong et al. (45)
Δμ0 Energy barrier for protein recruitment without mechanical load 1×105J/m2 Estimated from Nicolas et al. (21)
Δr Size of the recruited segment 10nm Estimated from Kanchanawong et al. (45)
ϕ0 Initial ligand density 1010m2 Cavalcanti-Adam et al. (46)
rc Cell radius 30μm Typical value of cell radius
rECM ECM radius 100μm Set much larger than cell size to eliminate boundary effect.