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. 2017 Jun 13;8:695. doi: 10.3389/fimmu.2017.00695

Figure 1.

Figure 1

The development and functions of innate lymphoid cell (ILC) subsets and their associated adaptive lymphocyte subsets. All ILCs arise from an early innate lymphoid precursor (EILP), which is generated from the common lymphoid progenitor (CLP). ILC1s, ILC2s, and ILC3s differentiate from a common helper-like innate lymphoid precursor (CHILP) arising from EILP. Conventional NK cells (cNK) differentiate from NK cell progenitors (NKPs) arising from EILPs. Lymphoid tissue inducer (LTi) cells are a subset of innate lymphocytes that interact with stromal cells to facilitate the development of lymphoid organs. The cytokines secreted by ILCs and helper T cells promote type 1, 2, and 3 immune responses. Group 1 ILCs contain cNK and ILC1s; group 2 ILCs is the all-inclusive term for ILC2s; group 3 ILCs comprise NCR+ILC3s, NCR−ILC3s, and LTis. Unlike other helper-like ILCs, ILC1s are dependent on IL-15 signaling and not on IL-7. AHR, aryl hydrocarbon receptor; E4BP4, E4 promoter-binding protein 4 (also known as NFIL3); GATA3, GATA-binding protein 3; ID2, inhibitor of DNA binding 2; NCR, natural cytotoxicity receptor; NKP, NK cell precursor; ROR, retinoic acid receptor-related orphan receptor; Th, T helper.