Figure 1.

Inflammation fosters CRC development in genetically engineered mice.

A) Macroscopic colon tumor counts from 12–51 week old SPF Apc^Min/+;Il10^−/− and Apc^Min/+ mice. B) Colon combined histological inflammation scores (the average of the proximal and distal inflammation scores) from SPF Apc^Min/+;Il10^−/− and Apc^Min/+ mice. C-D) Cecum and small intestine macroscopic tumor counts from SPF Apc^Min/+;Il10^−/− and Apc^Min/+ mice. E) Colon H&Es from 30–40 week old SPF Apc^Min/+;Il10^−/− and Apc^Min/+ mice (5×, 40× magnification). F) Relationship between colon inflammation score and macroscopic colon or small intestine tumors in SPF Apc^Min/+;Il10^−/− and Apc^Min/+ mice. G) Relationship between mouse endpoint age and macroscopic tumors in SPF Apc^Min/+;Il10^−/− and Apc^Min/+ mice. Spearman correlation r values and corresponding p values are noted in each panel. Data are expressed as mean +/− standard deviation (SD). Two-tailed Mann-Whitney statistical analysis: ****p< 0.0001, ***p< 0.001, **p< 0.01, *p< 0.05, NS: not significant.