Figure 3.

Simplified diagram, illustrating linkage between selected microRNAs (miRNA) and their potential target messenger RNAs (mRNA) and potential signaling pathways and cell functions. Differentially expressed miRNAs in active hives are placed together in either increased (five miRNAs as potential chronic autoimmune urticaria [CAU] biomarkers are shown in bold) or decreased boxes in the left-hand side. Likewise, the candidate target mRNAs are grouped as either down- or upregulated, or in the unknown boxes in the middle. Due to the complexity of the miRNA-mRNA network, only connections among miRNAs and the chosen candidate genes that were targets of three or more different miRNAs are shown in solid lines if they are in accordance (i.e., increased miRNA expression that corresponded to mRNAs decreased in chronic idiopathic urticaria [CIU], or decreased miRNA expression that corresponds to mRNAs increased in CIU) or in dashed lines if the status between them is unknown. Similarly, only pathways (in round boxes and italic) and possible cellular functions (in rectangular boxes) were shown if they were involved with at least three of the candidate genes with known functions.