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. 2017 Jun 12;17:150. doi: 10.1186/s12872-017-0576-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Associations between pulmonary hemodynamics and PDE5i effects. a Interpolated relationships from meta-regression analysis of the PDE5i-mediated reduction in PAP levels and the changes in peak VO₂ (Δpeak VO₂, mL/min/kg). b Interpolated relationships between the baseline PAP levels and the PDE5i-mediated reduction in PAP levels. Blue circles indicate the results from HFrEF trials; red circles indicate the results from HFpEF trials. Ages and proportions of male sex were used as covariates. Abbreviations: PAP, pulmonary arterial pressure; other abbreviations as in Fig. 2