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Baseline characteristics
| Patients | Overall Group (n = 187) |
|---|---|
| Disease type | |
| Hgb SS | 174 (93%) |
| Hgb Sβo | 13 (7%) |
| Age, mean (sd) | 13.5 (4.5) |
| Age group | |
| 4–11 years | 74 (40%) |
| 12–21 years | 113 (60%) |
| Sex | |
| Female | 94 (50%) |
| Treated with hydroxyurea within 3 months prior to randomization | 114 (61%) |
| History of acute chest syndrome | 143 (76%) |
| Hospitalizations for a pain crisis in past 3 years | |
| 0 | 16 (9%) |
| 1 | 23 (12%) |
| 2 | 25 (13%) |
| 3 | 29 (16%) |
| 4 | 17 (9%) |
| 5 | 13 (7%) |
| ≥ 6 | 63 (34%) |
