Table 1.
Model fitting results for an extended longitudinal bivariate Cholesky decomposition of internalizing disorders and insomnia
| Model | Variables | (Qual MDD or GAD/ Qual Ins) / Quan) | −2LL | AIC | DF | ΔDF | Δ(−2LL) | ΔAIC |
|---|---|---|---|---|---|---|---|---|
| MDD (Prevalence: 9.1% W1; 8.7% W2) | ||||||||
|
| ||||||||
| Sex differences and dropping A/C | ||||||||
| I | ACE | (+ / +) / + | 50242.34 | −14451.66 | 32347 | - | - | - |
| II | ACE | (+ / +) / − | - | - | - | 23 | 43.63 | −2.37 |
| III | ACE | (− / +) / + | - | - | - | 1 | 0.00 | −2.00 |
| IV | ACE | (+ / −) / + | - | - | - | 1 | 0.15 | −1.86 |
| V | ACE | (− / −) / + | - | - | - | 2 | 0.15 | −3.86 |
| VI | AE | (− / −) / + | - | - | - | 16 | 5.95 | −26.06 |
| VII | CE | (− / −) / + | - | - | - | 16 | 46.24 | 14.23 |
| Dropping time-specific effects | ||||||||
| VI | AE | (− / −) / + | 50248.29 | −14477.72 | 32363 | - | - | − |
| VIII | AsMDD = 0 | (− / −) / + | - | - | - | 4 | 1.20 | −6.79 |
| IX | AsIns = 0 | (− / −) / + | - | - | - | 4 | 8.70 | 0.71 |
| X | AsIns/MDD = 0 | (− / −) / + | - | - | - | 8 | 10.10 | −5.90 |
| XI | AsIns/MDD = 0, A22 = 0 | (− / −) / + | - | - | - | 9 | 20.60 | 2.61 |
| XII | AsIns/MDD = 0, E22 = 0* | (− / −) / + | - | - | - | 10 | 10.02 | −7.97 |
|
| ||||||||
| GAD (Prevalence: 5.8% W1; 7.9% W2) | ||||||||
|
| ||||||||
| Sex differences and dropping A/C | ||||||||
| I | ACE | (+ / +) / + | 48637.83 | −16050.18 | 32344 | - | - | - |
| II | ACE | (+ / +) / − | - | - | - | 23 | 29.92 | −16.08 |
| III | ACE | (− / +) / − | - | - | - | 24 | 29.92 | −18.08 |
| IV | ACE | (+ / −) / − | - | - | - | 24 | 31.81 | −16.19 |
| V | ACE | (− / −) / − | - | - | - | 25 | 31.81 | −18.19 |
| VI | AE | (− / −) / − | - | - | - | 32 | 32.83 | −31.17 |
| VII | CE | (− / −) / − | - | - | - | 32 | 62.85 | −1.15 |
| Dropping time-specific genetic effects | ||||||||
| VI | AE | (− / −) / − | 48670.65 | −16081.35 | 32376 | - | - | - |
| VIII | AsGAD = 0 | (− / −) / − | - | - | - | 2 | 3.90 | −0.10 |
| IX | AsIns = 0 | (− / −) / − | - | - | - | 2 | 1.45 | −2.54 |
| X | AsIns/GAD = 0 | (− / −) / − | - | - | - | 4 | 5.36 | −2.64 |
| XI | AsIns/GAD = 0, A22 = 0 | (− / −) / − | - | - | - | 5 | 7.04 | −2.96 |
Abbreviations: Qual=qualitative sex effect; quan=quantitative sex effect; (+) denotes that this sex effect was allowed to vary; (−) denotes that this sex effect was constrained; AsMDD or AsGAD = time-specific genetic effects for MDD or GAD; AsIns = time-specific genetic effects for insomnia; AsIns/MDD or AsIns/GAD = time-specific genetic effects for both MDD or GAD and insomnia; A22 = insomnia-specific genetic effect; E22 = insomnia-specific unique environmental effect.
*
E22 was fixed to zero in the MDD final model, since the parameter estimate was 0. Bold text indicates the best-fit model.