Table 2.
Main characteristics of the antibiotics used for the treatment of SSIs due to MRSA [8]
| Antibiotic | Bactericidal activity; pharmacodynamics; anti-biofilm activity | Route of administration | Doses | Adverse events | Interactions | Cost (for a 70 kg person) |
|---|---|---|---|---|---|---|
| Teicoplanin | Bactericidal with low MIC; time-dependent; None | iv, im | 7-10 mg/Kg once daily, loading dose | Renal toxicity | None | €50-70/day |
| Vancomycin | Bactericidal with low MIC; time-dependent; None | iv | 1 g twice daily, 500 mg four times a day | Renal toxicity | Other nephrotoxic drugs | €5/day |
| Daptomycin | Bactericidal; concentration-dependent; Yes | iv | 4-6 mg/kg | Myotoxicity | Statins | €80-120/day |
| Linezolid | Bacteriostatic; time-dependent; None | iv, oral | 1200 mg once daily | Bone marrow toxicity, neuropathy, serotoninergic syndrome | SSRIs | €120/day |
| Tigecycline | Bacteriostatic; time-dependent; Partial | iv | 50 mg twice daily; 100 mg loading dose | Nausea, vomiting, pancreatitis | None | €120/day |
| Ceftaroline | Bactericidal; time-dependent; None | iv | 600 mg twice daily | Rash | None | €96/day |
| Dalbavancin | Bactericidal; concentration-dependent; Yes | iv | 1000 mg day 1, 500 mg after 7 days; or 1500 mg one-shot | No | None | NA |
| Cotrimoxazole | Bactericidal; time-dependent; None | iv, oral | 800/160 mg 3 times a day | Anemia | None | €15/day |
| Rifampin | Bactericidal; time-dependent; Yes | iv, oral | 600 mg once a day | Liver toxicity | Several | €6/day |
iv intravenous, im intramuscular, SSRIs selective serotonin re-uptake inhibitors