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. 2017 Jun 12;9:64. doi: 10.1186/s13148-017-0363-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Pattern of methylation in matched pairs of head and neck tumors and adjacent normal mucosal tissues, and ROC curve analysis of NMV. a SALL3-P1 NMVs of head and neck tumors were higher than those of adjacent normal mucosal tissues (P < 0.001). b Area under the ROC curve (AUROC) for SALL3-P1 was 0.7407. c A higher frequency and degree of SALL3-P2 methylation was observed in head and neck tumors than in matched normal mucosae (P < 0.001). d AUROC value for SALL3-P2 was 0.7863. At the cutoff value of 0.11, sensitivity was 58.3% and specificity was 91.7%. e SALL3-P3 NMVs of head and neck tumors were higher than those of paired adjacent normal mucosae (P < 0.001) f AUROC value for SALL3-P3 was 0.7832