Table 2.
Genotype distributions and allele frequencies of LPL (rs320), LIPC (rs2070895), SCARB1 (rs5888), LCAT (rs2292318), CETP (rs708272), ADIPOQ (rs1501299), RETN (rs3745367), PON1 (rs662), and MNSOD (rs4880) gene polymorphisms in the study groups
| Gene/SNP | Genotype/haplotype | Patients with diabetic dyslipidemia n (%) | Control subjects n (%) | P |
|---|---|---|---|---|
| LPL (rs320) T495G | Wild type (TT) | 22 (10.1) | 148 (69.8) | <0.001 |
| Heterozygote (TG) | 82 (38) | 54 (25.5) | ||
| Polymorphic (GG) | 112 (51.9) | 10 (4.7) | ||
| T | 126 | 350 | ||
| G | 164 | 74 | ||
| LIPC (rs2070895) G250A | Wild type (GG) | 1 (0.5) | 156 (73.6) | <0.001 |
| Heterozygote (GA) | 46 (21.4) | 48 (21.4) | ||
| Polymorphic (AA) | 168 (78.1) | 8 (3.8) | ||
| G | 48 | 360 | ||
| A | 382 | 64 | ||
| SCARB1 (rs5888) C1050T | Wild type (CC) | 67 (30.9) | 166 (79.6) | <0.001 |
| Heterozygote (CT) | 85 (39.2) | 40 (18.9) | ||
| Polymorphic (TT) | 65 (30.0) | 6 (2.8) | ||
| C | 219 | 372 | ||
| T | 215 | 52 | ||
| LCAT (rs2292318) C511T | Wild type (CC) | 0 (0) | 150 (69.1) | <0.001 |
| Heterozygote (CT) | 38 (17.9) | 67 (30.9) | ||
| Polymorphic (TT) | 174 (82.1) | 0 (0) | ||
| C | 38 | 367 | ||
| T | 67 | 386 | ||
| CETP (rs708272) G279A | Wild type (GG) | 68 (31.3) | 150 (70.8) | <0.001 |
| Heterozygote (GA) | 112 (51.6) | 53 (25) | ||
| Polymorphic (AA) | 37 (17.1) | 9 (4.2) | ||
| G | 248 | 353 | ||
| A | 186 | 71 | ||
| ADIPOQ (rs1501299) G276T | Wild type (GG) | 130 (60.5) | 156 (73.6) | =0.01 |
| Heterozygote (GT) | 69 (32.1) | 49 (23.1) | ||
| Polymorphic (TT) | 16 (7.4) | 7 (3.3) | ||
| G | 329 | 361 | ||
| T | 101 | 63 | ||
| RETN (rs3745367) G299A | Wild type (GG) | 42 (19.4) | 122 (57.5) | <0.001 |
| Heterozygote (GA) | 101 (46.5) | 75 (35.4) | ||
| Polymorphic (AA) | 74 (34.1) | 15 (7.1) | ||
| G | 185 | 319 | ||
| A | 249 | 105 | ||
| PON1 (rs3745367) Q192R | Wild type (AA) | 110 (51.4) | 119 (56.1) | 0.611 |
| Heterozygote (AG) | 87 (40.7) | 77 (36.3) | ||
| Polymorphic (GG) | 17 (7.9) | 16 (7.5) | ||
| A | 307 | 315 | ||
| G | 121 | 109 | ||
| MNSOD (rs4880) Ala16Val | Wild type (CC) | 101 (46.5) | 164 (77.4) | <0.001 |
| Heterozygote (CT) | 75 (34.6) | 41 (19.3) | ||
| Polymorphic (TT) | 41 (18.9) | 7 (3.3) | ||
| C | 277 | 369 | ||
| T | 157 | 55 |
ADIPOQ - adiponectin; CETP - cholesterol ester transfer protein; LCAT - lecithin–cholesterol acyltransferase; LIPC - hepatic lipase; LPL - lipoprotein lipase; MNSOD - manganese-dependent superoxide dismutase; PON1 - paraoxonase; RETN - resistin; SCARB1 - scavenger receptor class B member 1.
Statistical analysis was performed using SPSS 18.0. The chi-square test was used to compare the genotype distribution and allele frequencies between the groups. The level of significance was accepted as P<0.05.