Table 1.
Characteristics of studies related to the associations of rs50515 and rs11591147 with lipids levels
| Author | Year | Ethnicity | Type of study | Sample size | SNP | Genotyping method | Age(year) | Sex(M/F) | MAF (%) | HWE |
|---|---|---|---|---|---|---|---|---|---|---|
| He, X M [27] | 2016 | Asians | C-C | 233 | rs505151 | PCR-RFLP | 63.95 ± 12.35 | 130/103 | 13.9 | 0.015 |
| Jeenduang, N1 [28] | 2015 | Asians | Cohort | 307 | rs505151 | PCR-RFLP | NA | 97/210 | 1.95 | 0.727 |
| Jeenduang, N2 [28] | 2015 | Asians | Cohort | 188 | rs505151 | PCR-RFLP | NA | 38/150 | 1.06 | 0.883 |
| Yuqian, Mo [29] | 2015 | Asians | C-C | 100 | rs505151 | TaqMan | 56.4 ± 11.7 | 58/42 | 7.19 | 0.000 |
| Anderson, J M1 [30] | 2014 | Caucasians | C-C | 171 | rs505151 | PCR-RFLP | 47 ± 7 | 108/55 | 12.6 | NA |
| Anderson, J M2 [30] | 2014 | Caucasians | C-C | 163 | rs505151 | PCR-RFLP | 55 ± 10 | 127/44 | 14.7 | NA |
| Slimani, A [31] | 2014 | Caucasians | C-C | 258 | rs505151 | PCR-RFLP | Case:55 (52–65) Control:61 (55–67) | 212/46 | 0.88 | 0.000 |
| Mayne, J [32] | 2013 | Caucasians | Cohort | 207 | rs505151 | PCR-RFLP | NA | NA | 0.036 | 0.591 |
| Aung, L H1 [33] | 2013 | Asians | Cohort | 567 | rs505151 | PCR-RFLP | 45.13 ± 13.35 | 456/111 | 0.021 | 0.60 |
| Aung, L H2 [33] | 2013 | Asians | Cohort | 785 | rs505151 | PCR-RFLP | 47.36 ± 14.34 | 573/212 | 0.026 | 0.453 |
| Meng yanhui [34] | 2011 | Asians | Cohort | 165 | rs505151 | PCR-RFLP | 66.49 ± 9.92 | 102/63 | 0.058 | 0.430 |
| Zeng jian [35] | 2011 | Asians | C-C | 212 | rs505151 | PCR-RFLP | NA | NA | 0.123 | 0.020 |
| Norata, G D [36] | 2010 | Caucasians | Cohort | 1541 | rs505151 | Taqman | 54.71 ± 10.97 | 621/923 | 0.024 | 0.32 |
| Hsu, L A1 [37] | 2009 | Asians | C-C | 202 | rs505151 | PCR-RFLP | 55.6 ± 10.5 | 171/31 | 0.046 | 0.513 |
| Hsu, L A2 [37] | 2009 | Asians | C-C | 614 | rs505151 | PCR-RFLP | 45.9 ± 10.4 | 325/289 | 0.060 | 0.381 |
| Polisecki, E [38] | 2008 | Caucasians | Cohort | 5416 | rs505151 | Taqman | 75.64 ± 3.38 | 2620/2795 | 0.030 | 0.072 |
| Scartezini, M [39] | 2007 | Caucasians | Cohort | 2444 | rs505151 | PCR-RFLP | 50–61 | 2444(M) | 0.065 | 0.788 |
| Evans, D [40] | 2006 | Caucasians | Cohort | 506 | rs505151 | PCR-RFLP | 44 ± 14 | 239/267 | 0.050 | 0.111 |
| Chen, SN [41] | 2005 | Caucasians | Cohort | 372 | rs505151 | PCR-RFLP | 58.8 ± 7.7 | 310/62 | 0.074 | 0.000 |
| Jeenduang, N1 [28] | 2015 | Asians | Cohort | 97 | rs11591147 | PCR-RFLP | NA | 97(M) | 0.031 | 0.753 |
| Jeenduang, N2 [28] | 2015 | Asians | Cohort | 209 | rs11591147 | PCR-RFLP | NA | NA | 0.019 | 0.778 |
| Bonnefond, A [42] | 2015 | Caucasians | C-C | 4319 | rs11591147 | Metabochip | 46.7 ± 10.0 | 2272/2246 | 0.020 | 0.179 |
| Saavedra, YG [43] | 2014 | Caucasians | Cohort | 560 | rs11591147 | PCR-RFLP | 37.0 ± 13.9 | 329/231 | 0.016 | 0.699 |
| Guella, I [44] | 2010 | Caucasians | c-c | 3453 | rs11591147 | Taqman | 39.6 ± 4.9 | 3039/414 | NA | NA |
| Strom, T B [45] | 2010 | Caucasians | Cohort | 1130 | rs11591147 | PCR-RFLP | 34 ± 13.3 | 536/594 | NA | NA |
| Huang, C C [46] | 2009 | Caucasians | Cohort | 1828 | rs11591147 | Taqman | 25.5 ± 3.4 | 852/916 | NA | NA |
| Humphries, S E [47] | 2009 | Caucasians | Cohort | 81 | rs11591147 | PCR-RFLP | 56 ± 3.6 | 81(M) | 0.253 | 0.840 |
| Polisecki, E [38] | 2008 | Caucasians | Cohort | 5413 | rs11591147 | Taqman | 75.64 ± 3.38 | 2619/2794 | 0.018 | 0.069 |
Abbreviations: C-C case-control, M male, F female, MAF minor allelic frequencies, HWE Hardy-Weinberg equilibrium, NA not assess