Table 2.
Characteristics of the studies related to the associations of rs50515 and rs11591147 with cardiovascular risk
| Author | Year | Ethnicity | Subgroup | Type of study | Sample size | SNP | Genotyping method | Age(year) | Sex (M/F) | MAF (%) | HWE (p) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| He, X M [27] | 2016 | Asians | CHD | C-C | 472 | rs505151 | PCR-RFLP | 62.80 ± 12.76 | 251/221 | 0.056 | 0.07 |
| Yuqian, Mo [29] | 2015 | Asians | CHD | C-C | 200 | rs505151 | Taqman | 55.55 ± 10.98 | 114/86 | 0.040 | 0.677 |
| Yangchun [48] | 2015 | Asians | MI | C-C | 342 | rs505151 | PCR-RELP | 58.38 ± 6.45 | 200/144 | 0.038 | 0.589 |
| Slimani, A1 [31] | 2014 | Asians | CHD | C-C | 258 | rs505151 | PCR-RFLP | Case:55 (52–65) Control:61 (55–67) | 212/46 | 0.068 | 0.552 |
| Slimani, A3 [31] | 2014 | Caucasians | IS | C-C | 346 | rs505151 | PCR-RELP | Case:66 (54.5–76.5) Control:49 (45–55) | 237/109 | 0.073 | 0.812 |
| Lei, Jing [49] | 2014 | Caucasians | IS | C-C | 756 | rs505151 | SNaPshot | 61.91 ± 112 | 425/331 | 0.056 | 0.925 |
| Meng yanhui [34] | 2011 | Asians | CHD | C-C | 345 | rs505151 | PCR-RFLP | 65.37 ± 13.06 | 200/180 | 0.039 | 0.587 |
| Zeng jian [35] | 2011 | Asians | CHD | C-C | 396 | rs505151 | PCR-RFLP | NA | NA | 0.057 | 0.055 |
| Guella, I [44] | 2010 | Caucasians | MI | C-C | 4643 | rs505151 | PCR-RELP | 36.69 ± 4.92 | 3317/420 | NA | NA |
| Hsu, L A [37] | 2009 | Asians | CHD | C-C | 816 | rs505151 | PCR-RFLP | 48.30 ± 11.23 | 496/320 | 0.060 | 0.381 |
| Scartezini, M [39] | 2007 | Caucasians | CHD | C-C | 2065 | rs505151 | PCR-RFLP | 56.16 ± 3.41 | 2065(M) | 0.033 | 0.465 |
| Abboud, S [50] | 2007 | Caucasians | IS | C-C | 564 | rs505151 | TaqMan | Case(53.5) Control(70.3) | NA | 0.075 | 0.012 |
| Saavedra, Y G3 [43] | 2014 | Caucasians | Cohort | Cohort | 560 | rs11591147 | PCR-RFLP | 37.0 ± 13.9 | 329/231 | 0.016 | 0.699 |
| Benn, M1 [21] | 2010 | Caucasians | C-C | C-C | 10,032 | rs11591147 | Taqman | 58.0 (44–690 | 4514/5518 | 0.012 | 0.676 |
| Benn, M2 [21] | 2010 | Caucasians | C-C | C-C | 26,013 | rs11591147 | Taqman | 59.8 (51–69) | 12746/13267 | 0.014 | 0.334 |
| Benn, M3 [21] | 2010 | Caucasians | C-C | C-C | 9654 | rs11591147 | Taqman | 60.0 (51–69) | 5599/4055 | 0.012(total) | 0.748 |
| Guella, I [44] | 2010 | Caucasians | C-C | C-C | 4733 | rs11591147 | Taqman | 39.6 ± 4.9 | 3039/414 | NA | NA |
| Huang, C C [46] | 2009 | Caucasians | Cohort | Cohort | 1828 | rs11591147 | Taqman | 25.52 ± 3.41 | 882/946 | 0.170 | 0.505 |
| Polisecki, E1 [38] | 2008 | Caucasians | Cohort | Cohort | 5413 | rs11591147 | Taqman | 75.64 ± 3.38 | 2619/2794 | 0.018 | 0.840 |
| Scartezini, M [39] | 2007 | Caucasians | C-C | C-C | 2444 | rs11591147 | PCR | 50–61 | 2444(M) | 0.010 | 0.074 |
Abbreviations: CHD coronary heart disease, MI myocardial infarction, IS ischemic stroke, C-C case-control, M male, F female, MAF minor allelic frequencies, HWE Hardy-Weinberg equilibrium, NA not assess