Table 4.
Associations of rs505151 and rs11591147 variants with cardiovascular risk
| SNP | Variant allele | Subgroup | No. of Study | Sample size | effect model | OR | 95% CI | P value | I2% | Phet | Begg’ (P) | Egger’s (P) | Venice criteria | Level of evidence |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs505151 | G | Asians | 8 | 1672 | random | 1.59 | (1.12,2.27) | 0.009 | 60 | 0.01 | 0.805 | 0.437 | BCA | Weak |
| rs505151 | G | Caucasians | 4 | 2369 | random | 1.31 | (1.04,1.65) | 0.02 | 0 | 0.45 | 0.042 | 0.229 | BAA | Moderate |
| rs505151 | G | Overall | 4041 | random | 1.50 | (1.19,1.89) | 0.0006 | 48 | 0.03 | 0.493 | 0.144 | BBA | Moderate | |
| rs11591147 | T | Caucasians | 9 | 66,090 | random | 0.77 | (0.60,0.98) | 0.031 | 59.9 | 0.015 | 0.216 | 0.165 | BCA | Weak |
Abbreviations: OR odds ratio, 95% CI 95% confidence interval