Table 1.
Background and clinical characteristics of three study populations
| Cohort A | Cohort B | Cohort C | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cryptococcal meningitis (N = 90) | Asymptomatic CRAG+ (N = 87) | HIV+ controls (N = 125) | |||||||||
| N | % or Median | (IQR) | N | % or Median | (IQR) | N | % or Median | (IQR) | A vs B P-value | B vs C P-value | |
| Age (years) | 90 | 36 | (30–40) | 87 | 31 | (27–39) | 125 | 37 | (32–41) | 0.02 | <0.001 |
| Sex | 90 | 87 | 125 | ||||||||
| Male | 60% | 51% | 32% | ||||||||
| Female | 40% | 49% | 68% | 0.21 | 0.007 | ||||||
| Education level (years) | 90 | 8 | (4–11) | 87 | 7 | (3–11) | 125 | 8 | (6–11) | 0.15 | 0.05 |
| < 7 years | 36% | 45% | 27% | ||||||||
| 7 to 12 years | 51% | 44% | 62% | ||||||||
| > 12 years | 13% | 11% | 10% | 0.45 | 0.02 | ||||||
| CD4 count (cells/uL) | 79 | 17 | (7–79) | 86 | 26 | (9–59) | 125 | 233 | (183–297) | 0.93 | <0.001 |
| Karnofsky score | 90 | 60 | (50–70) | 87 | 70 | (60–80) | 125 | 90 | (90–90) | <0.001 | <0.001 |
| 40 | 1% | 0% | 0% | ||||||||
| 50 | 28% | 11% | 0% | ||||||||
| 60 | 36% | 20% | 1% | ||||||||
| 70 | 29% | 26% | 0% | ||||||||
| 80 | 3% | 29% | 2% | ||||||||
| 90 | 3% | 14% | 97% | ||||||||
| International HIV dementia scale | 88 | 87 | 125 | ||||||||
| < =10 | 92% | 75% | 66% | ||||||||
| > 10 | 8% | 25% | 34% | 0.002 | 0.20 | ||||||
| CES depression scale | 88 | 23 | (16–30) | 87 | 18 | (10–26) | 125 | 9 | (5–17) | 0.007 | <0.001 |
| < 16 | 25% | 41% | 70% | ||||||||
| > =16 | 75% | 59% | 30% | 0.02 | <0.001 | ||||||
Twenty participants from the cryptococcal meningitis cohort and 28 asymptomatic CrAg + participants were excluded due to insufficient data to calculate a QNPZ-8 score. P-values were calculated from student’s T-test (comparing means), Mann-Whitney U test, and chi-square test as appropriate