. Author manuscript; available in PMC: 2018 Jun 1.

Published in final edited form as: Epilepsia. 2017 Apr 27;58(6):1073–1084. doi: 10.1111/epi.13764

Table 5.

Comparison of Mouse and Rat 6 Hz Pharmacology for ASDs with Unique or Mixed Mechanisms of Action

Compound	Mechanism of Action	ED₅₀ and PI
		Mouse Stimulus Intensity		Rat Stimulus Intensity
		1.5×CC₉₇ (32mA)	2×CC₉₇ (44mA)	1.5×CC₉₇	2×CC₉₇
Ethosuximide	T-type Ca²⁺ channels	167 (114–223) PI 2.0^a	271 (234–309) PI 1.3	172 (75–301) PI 1.1	242 (150–427) PI 0.8
Ezogabine	K+ channels	42.5 (32.1–53.6) PI 0.4	32.5 (20.7–46.3) PI 0.5	9.1 (3.9–14.5) PI 4.6	18.9 (12.9–28.4) PI 2.2
Gabapentin	α2δ subunit of voltage-gated Ca²⁺ channels	>350 PI n.c.	>500 PI n.c.	>300 PI n.c.	>300 PI n.c.
Levetiracetam	SV2A modulation	33.1 (9.9–81.2) PI>15.1	>1000 PI n.c.	13.8 (3.2–25.7) PI>7.2	>800 PI n.c.
Topiramate	Mixed	>300 PI<1.3^a	>300 PI<1.3	>300 PI n.c.	>300 PI n.c.
Sodium Valproate	Mixed	126 (94.5–152) PI 3.2	239 (193–266) PI 1.7	238 (167–309) PI 1.5	291 (243–347) PI 1.2

Not calculated (n.c.); Protective Index (PI; TD₅₀/ED₅₀)

Barton et al., 2001³

N=6–8 per group, 100–120g (rats), 20–30g (mice)