Table 1.
MIC determinations (μg ml−1) of ADEP derivatives against mycobacteria and B. subtilis.
| Strain / Medium | ADEP2 | ADEP4 | ADEP7 | ADEP8 | apramycin | isoniazid |
|---|---|---|---|---|---|---|
| Minimal medium | ||||||
| M. smegmatis mc2155 | 64 | >64 | >64 | >64 | nd | 4 |
| M. bovis BCG Pasteur | 16 (8) | >64 (16) | >64 (16) | 32 | 1 | 0.06 |
| M. tuberculosis H37Rv | 32 (16) | >64 | >64 | 32 | 1 | nd |
|
| ||||||
| 7H9 medium | ||||||
| M. bovis BCG Pasteur | 64 | >64 | >64 | 32 | nd | 0.06 |
|
| ||||||
| Mueller-Hinton broth | ||||||
| B. subtilis 168 fresh ADEP a | 0.06 | 0.13 | 0.25 | 0.03 | nd | nd |
| B. subtilis 168 preincubated ADEP b | 8 | 1 | 2 | 1 | nd | nd |
Data in brackets represent the concentration where partial growth inhibition was observed. nd, not determined.
a
MIC determinations using freshly diluted ADEP2.
b
MIC determinations using ADEP2, which had been pre-incubated for 9 days in Mueller-Hinton broth.